What is the Celiac Disease Profile (Comprehensive)?

The Celiac Disease Profile (Comprehensive) is a detailed antibody panel that helps diagnose Celiac Disease, an autoimmune condition triggered by gluten consumption. The profile typically includes important markers such as Tissue Transglutaminase (tTG) IgA & IgG, Deamidated Gliadin Peptide (DGP) IgA & IgG, Endomysial Antibody (EMA), and Total Serum IgA. The exact components may vary depending on the laboratory.

Who should take this test?

• Individuals with chronic diarrhea, bloating, abdominal pain, or constipation.
• Patients with unexplained iron deficiency anemia or nutritional deficiencies.
• People experiencing unexplained weight loss or chronic fatigue.
• Children with poor growth, delayed puberty, or failure to thrive.
• Individuals with a family history of Celiac Disease.
• Patients with autoimmune conditions such as Type 1 Diabetes, autoimmune thyroid disease, or dermatitis herpetiformis.
• Doctor-recommended evaluation for gluten-related autoimmune disorders.

Preparation & Test Process

Understanding Your Results

Positive antibody results suggest an increased likelihood of Celiac Disease or another gluten-related autoimmune disorder.

Negative results reduce the likelihood of Celiac Disease but may not completely exclude it, particularly in patients with IgA deficiency or those already following a gluten-free diet.

Additional investigations, including HLA-DQ2/DQ8 genetic testing or small intestinal biopsy, may be recommended in selected cases.

Results should always be interpreted by your gastroenterologist together with symptoms, dietary history, family history, and other clinical findings.

FAQs – Celiac Disease Profile (Comprehensive)